REFERENCES

LISTEN SECTION REFERENCES

Article "Have you ever experienced these symptoms?"

Boulton A.J., et al., Diabetic somatic neuropathies. Diabetes Care. 2004 Jun;27(6):1458-86.

Callaghan B.C., et al., Diabetic neuropathy: Clinical manifestations and current treatments. Lancet Neurol 2012; 11: 521-534.

Freynhagen R., et al., painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain. Curr Med Res Opin2006; 22(10):1911-1920.

Landmann G., SIG: Pain, Mind and Movement IV, Diagnosis and treatment of painful polyneuropathy. Psychiatrie & Neurologie, 2012; 5.

Miranda-Massari J.R. et al., Metabolic correction in the management of diabetic peripheral neuropathy. Improving clinical results beyond symptom control. Curr Clin Pharmacol. 2011; 6(4): 260-273.

Negrão L., et al., Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. Pain Management 2014; 4(3), 191–196.

Article "Some signs may be misleading, always talk to your doctor."

Callaghan B.C., et al., Diabetic neuropathy: Clinical manifestations and current treatments. Lancet Neurol 2012; 11: 521-534.

Katzberg H.D., Neurogenic muscle cramps. J Neurol (2015) 262:1814–1821.

Misra U.K., et al., Diagnostic approach to peripheral neuropathy. Ann Indian Acad Neurol. 2008 Apr-Jun; 11(2): 89–97.

Article "Which populations have a higher probability for nerve impairments?"

Andrès E., et al., VitaminB12 (cobalamin) deficiency in elderly people. CMAJ 2004; 171(3):251-259.

Briani C., et al., Cobalamin deficiency: clinical picture and radiological findings. Nutrients 2013, 5, 4521-4539.

Callaghan B.C., et al., Distal symmetric polyneuropathy A Review. JAMA 2015; Volume 314, Number 20.

Carmel R. and Agrawal Y.P., Failures of cobalamin assays in pernicious anemia. N Engl J Med 2012; 367:385-386.

De Rosa A, et al., Subacute combined degeneration of the spinal cord in a vegan. Clin Neurol Neurosurg. 2012 Sep;114(7):1000-1002.

Freemann R., Not all neuropathy in diabetes is of diabetic etiology: differential diagnosis of diabetic neuropathy. R. Curr Diab Rep (2009) 9: 423–431.

Head K.A., Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev. 2006 Dec;11(4):294-329.

Holzbach E., Thiamine absorption in alcoholic delirium patients. J Stud Alcohol 1996; 57: 581-584.

Kjeldby I.K., et al., Vitamin B6 deficiency and diseases in elderly people--a study in nursing homes. BMC Geriatr. 2013 Feb 8; 13:13.

O’Keeffe S.T., Thiamine deficiency in elderly people. Age and Ageing 2000; 29: 99-101.

Smith B.H. and Torrance N., Epidemiology of neuropathic pain and its impact on quality of life. Curr Pain Headache Rep 2012; 16:191–198.

Spinneker A., et al., Vitamin B6 status, deficiency and its consequences - an overview. Nutr Hosp. 2007;22(1):7-24.

Stabler S., Vitamin B12 Deficiency. N Engl J Med 2013; 368:149-160.

Article "Do you know how diabetes may impact on nerve health?"

Adaikalakoteswari A., et al., Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia—Link to renal status, glycemic control and vascular inflammation. Diabetes Res Clin Pract. 2012; 95(3): 415-424.

Boulton A.J., et al., Diabetic somatic neuropathies. Diabetes Care. 2004 Jun; 27(6): 1458-86.

Briani C., et al. Cobalamin deficiency: clinical picture and radiological findings. Nutrients 2013; 5: 4521-4539.

Callaghan B.C., et al., Distal symmetric polyneuropathy a review. JAMA 2015; Volume 314, Number 20.

Eliasson B., Cigarette smoking and diabetes. Prog Cardiovas Dis, 2003; 45(5): 405-413.

Head K.A., Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev. 2006 Dec; 11(4): 294-329.

Obeid R., et al., Serum vitamin B12 not reflecting vitamin B12 status in patients with type 2 diabetes. Biochimie 2013; 95: 1056-1061.

Polydefkis M., et al., The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy. Brain 2004; 127(Pt7): 1606-1615.

Smith B.H. and Torrance N., Epidemiology of neuropathic pain and its impact on quality of life. Curr Pain Headache Rep 2012; 16: 191–198.

Stabler S., Vitamin B12 Deficiency. N Engl J Med 2013; 368: 149-160.

QUIZ: "Should you listen carefully to your nerves?"

Callaghan B.C., et al., Distal symmetric polyneuropathy A Review. JAMA 2015; Volume 314, Number 20.

Head K.A., Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev 2006; 11(4):294-329.

Landmann G., SIG: Pain, Mind and Movement IV, Diagnosis and treatment of painful polyneuropathy. Psychiatrie & Neurologie, 2012; 5.

Vinik A.I., et al., Diabetic autonomic neuropathy. Diabetes Care, 2003 May; 26(5): 1553-1579.

Article "10 facts you should know about the signs sent by nerves"

Callaghan B.C., et al., Diabetic neuropathy: Clinical manifestations and current treatments. Lancet Neurol 2012; 11: 521-534.

Callaghan B.C., et al., Distal symmetric polyneuropathy a Review. JAMA 2015; Volume 314, Number 20.

Freynhagen R. and Bennett M.I., Diagnosis and management of neuropathic pain. BMJ 2009; 339:b3002.

Head K.A., Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev. 2006 Dec; 11(4): 294-329.

http://www.telegraph.co.uk/music/news/the-disease-that-could-end-eric-claptons-career-why-musicians-fe/

LEARN SECTION REFERENCES

Article "How does the nervous system work?"

Hildebrand C., et al, Myelinated nerve fibres in the CNS. Prog Neurobiol. 1993 Mar;40(3):319-84.

Simons M. and Trotter J., Wrapping it up: the cell biology of myelination. Curr Opin Neurobiol. 2007 Oct;17(5):533-40. Epub 2007 Oct 17.

Swenson R.S., Review of clinical and functional neuroscience. 2006, Dartmouth Medical School.

Article "What happens when nerves are damaged?"

Katzberg H.D., Neurogenic muscle cramps, J Neurol. 2015; 262: 1814–1821.

Simons M. and Trotter J., Wrapping it up: the cell biology of myelination; Curr Opin Neurobiol. 2007 Oct;17(5):533-540.

Nix W.A., Muscles, Nerves, and Pain, A Guide to Diagnosis, Pain Concepts and Therapy, Springer-Verlag Berlin Heidelberg. 2012.

Swenson R.S., Review of clinical and functional neuroscience, Dartmouth Medical School, 2006.

Article "What are neurotropic B vitamins?"

Adamo A.M., Nutritional factors and aging in demyelinating diseases. Genes Nutr 2014; 9:360.

Bender D., B vitamins in the nervous system, Neurochem. Int. 1984; 6(3): 297 321.

Bernstein, A. L., Vitamin B6 in clinical neurology. Annals of the New York Academy of Sciences, 1990; 585: 250–260.

Dakshinamurti K., Paulose C.S., Viswanathan M., et al., Neurobiology of pyridoxine. Annals of the New York Academy of Sciences 1990;585:128-44.

Elmofty D.H. et al., Best practices in the treatment of neuropathic pain. Pain Manage. 2013; 3(6): 475-483.

Frye R.E. and Jabbour S.A., Pyridoxine Deficiency. Secondary Pyridoxine Deficiency 2014. http://emedicine.medscape.com/article/124947-overview#showall.

Gröber U., et al., Neuroenhancement with Vitamin B12—Underestimated Neurological Significance Nutrients 2013, 5, 5031-5045.

Head K.A., Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Res 2006; 11(4):294-329.

Negrão L., et al., Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. Pain Management 2014; 4(3), 191–196.

Singleton C.K. and Martin P.R., Molecular mechanisms of thiamine utilization. Curr Mol Med 2001;1(2):197-207.

Spinneker A., et al., Vitamin B6 status, deficiency and its consequences - an overview. Nutr Hosp. 2007;22(1):7-24.

Sriram K., et al., Thiamine in nutrition therapy. Nutr Clin Pract 2012;27(1):41-50.

Stabler S.P., Vitamin B12 deficiency. New Eng J Med 2013;368(21):2041-2.

Zhang M., et al., Methylcobalamin: a potential vitamin of pain killer. Neural Plast 2013;2013:424651.

Article "When do you need treatment with neurotropic B vitamins?"

Bernstein A.L., Vitamin B6 in clinical neurology. Ann N Y Acad Sci. 1990; 585: 250-260.

Briani C., et al., Cobalamin deficiency: clinical picture and radiological findings. Nutrients 2013; 5(11): 4521-4539.

Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press, 1998.

Janka H.U., et al., The influence of Neurobion on the temperature sensibility in patients with diabetic polyneuropathy. Int. Rietbrock N, ed. Pharmakologie und klinische Anwendung hochdosierter B-vitamine. Darmstadt: Steinkopff Verlag, 1991: 87-97.

Jolivalt C.G., et al., B vitamins alleviate indices of neuropathic pain in diabetic rats. Eur J Pharmacol 2009; 612(1-3): 41-47.

Langan R.C. and Zawistoski K.J., Update on Vitamin B12 Deficiency, Am Fam Physician. 2011 Jun 15; 83(12): 1425-1430.

Reyes-Garcia G., et al., Analgesic effects of B vitamins: A review. Curr Topics in Pharmacology 2006; 10(1).

Singleton C.K. and Martin P.R., Molecular mechanisms of thiamine utilization. Curr Mol Med 2001; 1(2): 197-207.

Sriram K., et al., Thiamine in nutrition therapy. Nutr Clin Pract 2012; 27(1): 41-50.

Watanabe T., et al., Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. Journal of the neurological sciences 1994; 122(2): 140-143.

Zhang M., et al., Methylcobalamin: a potential vitamin of pain killer. Neural Plast 2013; 2013: 424651.

Article "What is peripheral neuropathy?"

Boulton A.J.M., et al., Diabetic somatic neuropathies. Diabetes Care 2004; 27: 1458-1486.

Callaghan B.C., et al., Distal symmetric polyneuropathy a Review. JAMA 2015; Volume 314, Number 20.

Head K.A., Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev 2006; 11(4): 294-329.

Landmann G., SIG: Pain, mind and movement IV, diagnosis and treatment of painful polyneuropathy, Psychiatrie & Neurologie, 2012; 5.

Misra U.K., et al., Diagnostic approach to peripheral neuropathy. Ann Indian Acad Neurol. 2008 Apr-Jun; 11(2): 89–97.

Article "Why is early diagnosis important for nerve health?"

Misra U.K. et al., Diagnostic approach to peripheral neuropathy. Ann Indian Acad Neurol. 2008 Apr-Jun; 11(2): 89–97.

Mulvey M.R., et al., The role of screening tools in diagnosing neuropathic pain. Pain manag. 2014; 4(3): 233-243.

Okada K., et al., Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model. Exp Neurol (2010) Apr;222(2): 191–203.

Polydefkis M., et al., The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy. Brain (2004), 127 (7): 1606-1615.

Vinik A.I., Neuropathy: new concepts in evaluation and treatment. South Med J. 2002;95(1):21-3.

Article "10 fascinating facts about the nervous system"

Elmofty D.H., et al., Best practices in the treatment of neuropathic pain. Pain Manage. 2013; 3(6): 475-483.

Head K.A., Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Res 2006; 11(4):294-329.

Herculano-Houzel S., et al., The elephant brain in numbers. Front. Neuroanat. 2014, 8:46.

Hildebrand C., et al., Myelinated nerve fibres in the CNS. Prog Neurobiol. 1993 Mar;40(3):319-84.

Mancini F, et al., Whole-body mapping of spatial acuity for pain and touch. Ann Neurol. 2014 Jun;75(6):917-24.

Negrão L., et al., Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. Pain Management 2014; 4(3), 191–196.

Polydefkis M., et al., The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy. Brain (2004), 127 (7): 1606-1615.

Stabler S.P., Vitamin B12 deficiency. New Eng J Med 2013;368(21):2041-2.

Swenson R.S., Review of clinical and functional neuroscience. 2006, Dartmouth Medical School.

Quiz: "Test your knowledge of nerves"

Hildebrand C., et al., Myelinated nerve fibres in the CNS. Prog Neurobiol. 1993 Mar;40(3):319-84.

Misra U.K. et al., Diagnostic approach to peripheral neuropathy. Ann Indian Acad Neurol. 2008 Apr-Jun; 11(2): 89–97.

Mulvey M.R., et al., The role of screening tools in diagnosing neuropathic pain. Pain manag. 2014; 4(3): 233-243.

Polydefkis M., et al., The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy. Brain (2004), 127 (7): 1606-1615.

Simons M. and Trotter J., Wrapping it up: the cell biology of myelination. Curr Opin Neurobiol. 2007 Oct;17(5):533-40. Epub 2007 Oct 17.

Swenson R.S., Review of clinical and functional neuroscience. 2006, Dartmouth Medical School.

CARE SECTION REFERENCES

Article "Lifestyle tips for populations with a higher probability for nerve impairments"

Callaghan B.C. et al., Diabetic neuropathy: Clinical manifestations and current treatments. Lancet Neurol 2012; 11: 521-534.

Dobson J.L. et al., Benefits of exercise intervention in reducing neuropathic pain, Front Cell Neurosci, 2014 Apr.

Handsaker J.C., et al., Resistance exercise training increases lower limb speed of strength generation during stair ascent and descent in people with diabetic peripheral neuropathy. Diabet Med. 2016 Jan;33(1):97-104.

Head K.A., Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev 2006; 11(4):294-329.

Huizinga M.M., et al., Painful diabetic neuropathy: A management-centered review. Clinical Diabetes 2007 Jan; 25(1): 6-15.

Kluding P.M., et al., The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy. J Diabetes Complications. 2012 Sep; 26(5): 424–429.

Landmann G., SIG: Pain, Mind and Movement IV, Diagnosis and treatment of painful polyneuropathy, Psychiatrie & Neurologie, 2012; 5.

Streckmann F., et al., Exercise intervention studies in patients with peripheral neuropathy: a systematic review. Sports Med. 2014 Sep;44(9):1289-304.

Article "Good habits for living with nerve discomforts"

Callaghan B.C., et al., Diabetic neuropathy: Clinical manifestations and current treatments. Lancet Neurol 2012; 11: 521-534.

Head K.A., Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev 2006; 11(4):294-329.

Huizinga M.M., et al., Painful diabetic neuropathy: A management-centered review. Clinical Diabetes 2007 Jan; 25(1): 6-15.

Jensen M.P., et al., The impact of neuropathic pain on health-related quality of life. Review and implications. Neurology, 2007; 68:1178–1182.

Katzberg H D., Neurogenic muscle cramps. J Neurol 2015; 262:1814–1821.

Narayan K.M., et al., Diabetes — a common, growing, serious, costly, and potentially preventable public health problem. Diab Res and Clin Pract 50 Suppl. 2 (2000) S77–S84.

Nicholson B., Differential diagnosis: nociceptive and neuropathic pain. Am J Manag Care. 2006 Jun;12(9 Suppl):S256-62.

O’Connor A., Neuropathic pain. Quality-of-life impact, costs, and cost effectiveness of therapy. Pharmacoeconomics, 2009; 27(2), 95–112.

Smith B.H. and Torrance N., Epidemiology of neuropathic pain and its impact on quality of life. Curr Pain Headache Rep (2012) 16:191–198.

Article "Treatment options for nerve impairments"

Head K., Peripheral neuropathy: pathogenic mechanisms and alternative therapies, Altern Med Rev. 2006 Dec; 11(4): 294-329.

Huizinga M.M. and Peltier A., Painful diabetic neuropathy: a management-centered review, Clinical Diabetes 2007 Jan; 25(1): 6-15.

Landmann G., SIG: Pain, mind and movement IV, diagnosis and treatment of painful polyneuropathy, Psychiatrie & Neurologie, 2012; 5.

Rizvi A., et al., Efficacy of combination of vitamin B1, B6 and B12 in management of diabetic peripheral neuropathy. PJMHS 2007, vol. 7, no. 3.

QUIZ: "Do you have a good lifestyle?"

Streckmann F., et al., Exercise intervention studies in patients with peripheral neuropathy: a systematic review. Sports Med. 2014 Sep;44(9):1289-304.

Article "10 tips for a better quality of life and nerve health"

Dobson J.L., et al., Benefits of exercise intervention in reducing neuropathic pain. Front Cell Neurosci. 2014; 8: 102.

Head K., Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev. 2006 Dec; 11(4): 294-329.

Streckmann F., et al., Exercise intervention studies in patients with peripheral neuropathy: a systematic review. Sports Med. 2014 Sep; 44(9): 1289-1304.