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REFERENCES

 

 

 

LISTEN SECTION REFERENCES

 

 

Article "Have you ever experienced these symptoms?"

 

Boulton A.J., et al., Diabetic somatic neuropathies. Diabetes Care. 2004 Jun;27(6):1458-86.

 

Callaghan B.C., et al., Diabetic neuropathy: Clinical manifestations and current treatments. Lancet Neurol 2012; 11: 521-534.

 

Freynhagen R., et al., painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain. Curr Med Res Opin2006; 22(10):1911-1920.

 

Landmann G., SIG: Pain, Mind and Movement IV, Diagnosis and treatment of painful polyneuropathy. Psychiatrie & Neurologie, 2012; 5.

 

Miranda-Massari J.R. et al., Metabolic correction in the management of diabetic neuropathy. Improving clinical results beyond symptom control. Curr Clin Pharmacol. 2011; 6(4): 260-273.

 

Negrão L., et al., Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of neuropathies. Pain Management 2014; 4(3), 191–196.

 

 

Article "Some signs may be misleading, always talk to your doctor."

 

Callaghan B.C., et al., Diabetic neuropathy: Clinical manifestations and current treatments. Lancet Neurol 2012; 11: 521-534.

 

Katzberg H.D., Neurogenic muscle cramps. J Neurol (2015) 262:1814–1821.

 

Misra U.K., et al., Diagnostic approach to neuropathy. Ann Indian Acad Neurol. 2008 Apr-Jun; 11(2): 89–97.

 

 

Article "Which populations have a higher probability for nerve impairments?"

 

Andrès E., et al., VitaminB12 (cobalamin) deficiency in elderly people. CMAJ 2004; 171(3):251-259.

 

Briani C., et al., Cobalamin deficiency: clinical picture and radiological findings. Nutrients 2013, 5, 4521-4539.

 

Callaghan B.C., et al., Distal symmetric polyneuropathy A Review. JAMA 2015; Volume 314, Number 20.

 

Carmel R. and Agrawal Y.P., Failures of cobalamin assays in pernicious anemia. N Engl J Med 2012; 367:385-386.

 

De Rosa A, et al., Subacute combined degeneration of the spinal cord in a vegan. Clin Neurol Neurosurg. 2012 Sep;114(7):1000-1002.

 

Freemann R., Not all neuropathy in diabetes is of diabetic etiology: differential diagnosis of diabetic neuropathy. R. Curr Diab Rep (2009) 9: 423–431.

 

Head K.A., neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev. 2006 Dec;11(4):294-329.

 

Holzbach E., Thiamine absorption in alcoholic delirium patients. J Stud Alcohol 1996; 57: 581-584.

 

Kjeldby I.K., et al., Vitamin B6 deficiency and diseases in elderly people--a study in nursing homes. BMC Geriatr. 2013 Feb 8; 13:13.

 

O’Keeffe S.T., Thiamine deficiency in elderly people. Age and Ageing 2000; 29: 99-101.

 

Smith B.H. and Torrance N., Epidemiology of neuropathic pain and its impact on quality of life. Curr Pain Headache Rep 2012; 16:191–198.

 

Spinneker A., et al., Vitamin B6 status, deficiency and its consequences - an overview. Nutr Hosp. 2007;22(1):7-24.

 

Stabler S., Vitamin B12 Deficiency. N Engl J Med 2013; 368:149-160.

 

 

QUIZ: "Should you listen carefully to your nerves?"

 

Callaghan B.C., et al., Distal symmetric polyneuropathy A Review. JAMA 2015; Volume 314, Number 20.

 

Head K.A., neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev 2006; 11(4):294-329.

 

Landmann G., SIG: Pain, Mind and Movement IV, Diagnosis and treatment of painful polyneuropathy. Psychiatrie & Neurologie, 2012; 5.

 

Vinik A.I., et al., Diabetic autonomic neuropathy. Diabetes Care, 2003 May; 26(5): 1553-1579.

 

 

LEARN SECTION REFERENCES

 

 

Article "How does the nervous system work?"

 

Hildebrand C., et al, Myelinated nerve fibres in the CNS. Prog Neurobiol. 1993 Mar;40(3):319-84.

 

Simons M. and Trotter J., Wrapping it up: the cell biology of myelination. Curr Opin Neurobiol. 2007 Oct;17(5):533-40. Epub 2007 Oct 17.

 

Swenson R.S., Review of clinical and functional neuroscience. 2006, Dartmouth Medical School.

 

 

Article "What are neurotropic B vitamins?"

 

Adamo A.M., Nutritional factors and aging in demyelinating diseases. Genes Nutr 2014; 9:360.

 

Bender D., B vitamins in the nervous system, Neurochem. Int. 1984; 6(3): 297 321.

 

Bernstein, A. L., Vitamin B6 in clinical neurology. Annals of the New York Academy of Sciences, 1990; 585: 250–260.

 

Dakshinamurti K., Paulose C.S., Viswanathan M., et al., Neurobiology of pyridoxine. Annals of the New York Academy of Sciences 1990;585:128-44.

 

Elmofty D.H. et al., Best practices in the treatment of neuropathic pain. Pain Manage. 2013; 3(6): 475-483.

 

Frye R.E. and Jabbour S.A., Pyridoxine Deficiency. Secondary Pyridoxine Deficiency 2014. http://emedicine.medscape.com/article/124947-overview#showall.

 

Gröber U., et al., Neuroenhancement with Vitamin B12—Underestimated Neurological Significance Nutrients 2013, 5, 5031-5045.

 

Head K.A., neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Res 2006; 11(4):294-329.

 

Negrão L., et al., Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of neuropathies. Pain Management 2014; 4(3), 191–196.

 

Singleton C.K. and Martin P.R., Molecular mechanisms of thiamine utilization. Curr Mol Med 2001;1(2):197-207.

 

Spinneker A., et al., Vitamin B6 status, deficiency and its consequences - an overview. Nutr Hosp. 2007;22(1):7-24.

 

Sriram K., et al., Thiamine in nutrition therapy. Nutr Clin Pract 2012;27(1):41-50.

 

Stabler S.P., Vitamin B12 deficiency. New Eng J Med 2013;368(21):2041-2.

 

Zhang M., et al., Methylcobalamin: a potential vitamin of pain killer. Neural Plast 2013;2013:424651.

 

 

Article "Why is early diagnosis important for nerve health?"

 

Misra U.K. et al., Diagnostic approach to neuropathy. Ann Indian Acad Neurol. 2008 Apr-Jun; 11(2): 89–97.

 

Mulvey M.R., et al., The role of screening tools in diagnosing neuropathic pain. Pain manag. 2014; 4(3): 233-243.

 

Okada K., et al., Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model. Exp Neurol (2010) Apr;222(2): 191–203.

 

Polydefkis M., et al., The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy. Brain (2004), 127 (7): 1606-1615.

 

Vinik A.I., Neuropathy: new concepts in evaluation and treatment. South Med J. 2002;95(1):21-3.

 

 

Article "10 fascinating facts about the nervous system"

 

Elmofty D.H., et al., Best practices in the treatment of neuropathic pain. Pain Manage. 2013; 3(6): 475-483.

 

Head K.A., neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Res 2006; 11(4):294-329.

 

Herculano-Houzel S., et al., The elephant brain in numbers. Front. Neuroanat. 2014, 8:46.

 

Hildebrand C., et al., Myelinated nerve fibres in the CNS. Prog Neurobiol. 1993 Mar;40(3):319-84.

 

Mancini F, et al., Whole-body mapping of spatial acuity for pain and touch. Ann Neurol. 2014 Jun;75(6):917-24.

 

Negrão L., et al., Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of neuropathies. Pain Management 2014; 4(3), 191–196.

 

Polydefkis M., et al., The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy. Brain (2004), 127 (7): 1606-1615.

 

Stabler S.P., Vitamin B12 deficiency. New Eng J Med 2013;368(21):2041-2.

Swenson R.S., Review of clinical and functional neuroscience. 2006, Dartmouth Medical School.

 

 

Quiz: "Test your knowledge of nerves"

 

Hildebrand C., et al., Myelinated nerve fibres in the CNS. Prog Neurobiol. 1993 Mar;40(3):319-84.

 

Misra U.K. et al., Diagnostic approach to neuropathy. Ann Indian Acad Neurol. 2008 Apr-Jun; 11(2): 89–97.

 

Mulvey M.R., et al., The role of screening tools in diagnosing neuropathic pain. Pain manag. 2014; 4(3): 233-243.

 

Polydefkis M., et al., The time course of epidermal nerve fibre regeneration: studies in normal controls and in people with diabetes, with and without neuropathy. Brain (2004), 127 (7): 1606-1615.

 

Simons M. and Trotter J., Wrapping it up: the cell biology of myelination. Curr Opin Neurobiol. 2007 Oct;17(5):533-40. Epub 2007 Oct 17.

 

Swenson R.S., Review of clinical and functional neuroscience. 2006, Dartmouth Medical School.

 

 

CARE SECTION REFERENCES

 

 

Article "Lifestyle tips for populations with a higher probability for nerve impairments"

 

Callaghan B.C. et al., Diabetic neuropathy: Clinical manifestations and current treatments. Lancet Neurol 2012; 11: 521-534.

 

Dobson J.L. et al., Benefits of exercise intervention in reducing neuropathic pain, Front Cell Neurosci, 2014 Apr.

 

Handsaker J.C., et al., Resistance exercise training increases lower limb speed of strength generation during stair ascent and descent in people with diabetic neuropathy. Diabet Med. 2016 Jan;33(1):97-104.

 

Head K.A., neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev 2006; 11(4):294-329.

 

Huizinga M.M., et al., Painful diabetic neuropathy: A management-centered review. Clinical Diabetes 2007 Jan; 25(1): 6-15.

 

Kluding P.M., et al., The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic neuropathy. J Diabetes Complications. 2012 Sep; 26(5): 424–429.

 

Landmann G., SIG: Pain, Mind and Movement IV, Diagnosis and treatment of painful polyneuropathy, Psychiatrie & Neurologie, 2012; 5.

 

Streckmann F., et al., Exercise intervention studies in patients with neuropathy: a systematic review. Sports Med. 2014 Sep;44(9):1289-304.

 

 

Article "Good habits for living with nerve discomforts"

 

Callaghan B.C., et al., Diabetic neuropathy: Clinical manifestations and current treatments. Lancet Neurol 2012; 11: 521-534.

 

Head K.A., neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev 2006; 11(4):294-329.

 

Huizinga M.M., et al., Painful diabetic neuropathy: A management-centered review. Clinical Diabetes 2007 Jan; 25(1): 6-15.

 

Jensen M.P., et al., The impact of neuropathic pain on health-related quality of life. Review and implications. Neurology, 2007; 68:1178–1182.

 

Katzberg H D., Neurogenic muscle cramps. J Neurol 2015; 262:1814–1821.

 

Kluding P.M., et al., The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic neuropathy. J Diabetes Complications. 2012 Sep; 26(5): 424–429.

 

Narayan K.M., et al., Diabetes — a common, growing, serious, costly, and potentially preventable public health problem. Diab Res and Clin Pract 50 Suppl. 2 (2000) S77–S84.

 

Nicholson B., Differential diagnosis: nociceptive and neuropathic pain. Am J Manag Care. 2006 Jun;12(9 Suppl):S256-62.

 

O’Connor A., Neuropathic pain. Quality-of-life impact, costs, and cost effectiveness of therapy. Pharmacoeconomics, 2009; 27(2), 95–112.

 

Smith B.H. and Torrance N., Epidemiology of neuropathic pain and its impact on quality of life. Curr Pain Headache Rep (2012) 16:191–198.

 

 

QUIZ: "Do you have a good lifestyle?"

 

Handsaker J.C., et al., Resistance exercise training increases lower limb speed of strength generation during stair ascent and descent in people with diabetic neuropathy. Diabet Med. 2016 Jan;33(1):97-104.

 

Kluding P.M., et al., The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic neuropathy. J Diabetes Complications. 2012 Sep; 26(5): 424–429.

 

Streckmann F., et al., Exercise intervention studies in patients with neuropathy: a systematic review. Sports Med. 2014 Sep;44(9):1289-304.

 

 

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Disclaimer

For adults only. One tablet daily as directed by the physician. Conditions might not improve if they are due to reasons other than lack of Vitamin Bs present in Neurobion Forte Tablets. For more information, consult your physician. No. 1 as per IQVIA SSA MAT MAY 2018 dataset in terms of units in Vitamin/Minerals/ Nutrients category. Results may vary from person to person.

The data contained in this website is intended for general reference only and is meant for viewers in India only. It may refer to pharmaceutical products, diagnostic techniques, therapeutics or indications not yet registered or approved in a given country and it should be noted that, over time, currency and completeness of the data may change. For updated information, please contact the Company. This data should not be used to diagnose, treat, cure or prevent any disease or condition without the professional advice of a Registered Medical Practitioner, and does not replace medical advice or a thorough medical examination. Registered Medical Practitioners should use their independent professional judgement in checking the symptoms, diagnosing & suggesting the appropriate line of treatment for patients. Merck is not in any way influencing, propagating or inducing anyone to buy or use Merck products. Merck accepts no liability for any loss, damage or compensation claims in connection with any act or omission by anyone based on information contained in or derived through use of this website. Duplication of or copying any data requires prior permission of the copyright holder. Canadian Residents should consult the EMD Serono Canada Inc. website at www.emdserono.ca for information on products and services approved in Canada. US Residents should consult EMD Serono, Inc. website at www.emdserono.com for information on products and services approved in the United States of America.